I will explain a constantly asked question I get, "Why do Vampires & Lycans fight each other?" It all goes back to the 1400s, where Vampires were hidden in plain sight and Lycans were forced out of hiding.
People had started to find more and more Lycans in their homes, schools, churches and neighborhoods. When they did find one they would wait until the dead of night and strap the man's/woman's limbs to a board with sliver laced rope and then they would cut off the head and feed it to their hunting dogs (so they would develop a taste for it.) Eventually, the Lycans learned that they were being hunted and started fleeing to the current Lycan king (Saragraph Van Less). They implored him to help them and the king judged that they would take refuge with the current Vampire lord (Vlad III A.K.A. Vlad the Impaler).
When they arrived, Vlad had the choice to either help them or shove them away. The two leaders conversed in private, Saragraph pleaded for sanctuary and Vlad refused because with the Lycans gone, Vlad would assume a seat on the council of Magi which Vampires had been trying to obtain for centuries. When the Lycans were leaving, Saragraph said one last thing to Vlad "Watch your sides, Vlad." and with that the Lycans left.
Months went by and Vlad began to grow paranoid, he knew that Lycans were very good at being stealthy and therefor, was always on guard. Pretty soon he became so paranoid that whenever someone walked in to his castle, he would throw sliver at them then tell them to pick it up, if they did so with no problem, he would see them. The Lycans tried several times to kill him, never reaveling their true nature.
Finally, one day a woman came to Vlad and told him that her farm was attacked by a big, great, wolf. Vlad took his most trusted mortal generals, Vlad's first mistake, and they rode off to the farm. When they arrived they spilt up, Vlad's second mistake. When Vlad called for them all he heard was howling in response. Saragraph approached him and said, "I told you to watch your sides. You Vamps, always think you are SO smart that you don't even see that the people closest to you are WOLVES".
It was true; Saragraph had switched Vlad's generals with some of his own men. Then the hunt was on. Saragraph chased Vlad all the way through the forest that nestled near the farm, Vlad's third mistake, when they reached a clearing Vlad tried to fight Saragraph, Vlad's fourth and final mistake. The last sentence I typed is the root of the modern feud; Vampires think that Saragraph swung first while Lycans think that Vlad did. Since no one else was around, there is no way of knowing. Whoever swung first would have been sentenced to death by the council.
On a normal night, the two would have been evenly matched but, what Vlad was forgetting was, IT WAS A FULL MOON. Saragraph destroyed Vlad with ease and by the time the two Lycans had caught up with them, it was over.
After that the new Vampire lord decreed that Lycans were the number one enemy of the Vampires. Lycans felt the same towards Vampires.